Nucleoside analogs as a rich source of antiviral agents active. Nucleoside analogues, in which the phosphoric ester group is replaced by the corresponding phosphonomethyl group, represent an important. Analogs of nucleosides and nucleotides are used clinically as medicinal agents such as. A series of c8substituted4thioadenosine analogs 3a3g, 15, and 17 and their truncated derivatives 4a4j, 2325, and 27 have been successfully synthesized from d. The nucleoside analogues are an important class of antiviral agents now.
As a service to our customers we are providing this early version of the manuscript. Nucleic acid medicine synthesis research reagents pdf file. Nucleoside 5triphosphate ntp analogues are valuable tools for biochemical and medicinal research. Inhibitors of intracellular nucleoside synthesis and newly discovered. Nucleosides, nucleotides, oligonucleotides tci europe n. This is a pdf file of an unedited manuscript that has been accepted for publication. Design, synthesis and evaluation of a series of acyclic. This dissertation, written by ramanjaneyulu rayala, and entitled design and synthesis of novel nucleoside analogues. The synthesis of novel nucleoside analogues bearing a c3. The synthesized compounds were evaluated for their antiplasmodial activity in.
Therefore, a facile and efficient synthesis of ntp analogues is required. Nucleoside analogues are nucleosides which contain a nucleic acid analogue and a sugar. Phosphoramidite analogues of modified cyclotriphosphates provide a general and stepeconomical synthesis of nucleoside triphosphates and analogues on scale without the need for protecting groups. Chemical synthesis of nucleoside analogues request pdf. Oxidative and reductive approaches toward synthesis of 2fluoro pyrimidine nucleosides, having been approved in respect to style and intellectual content, is referred to you for judgment. Chemical synthesis of nucleoside analogues covers all the major classes of nucleosides, including pronucleotides, cnucleosides, carbanucleosides, and pna monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The synthesis of a novel nucleoside phosphonate constructed on a branchedthreotetrofuranose scaffold, as a potential antiviral agent, is described. Inhibition of nucleoside transport and proliferation of cancer cells. Design and synthesis of a nucleoside and a phosphonate. Synthesis and antiplasmodial activity of purinebased cnucleoside. The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis. Design and synthesis of novel nucleoside analogues.
Diastereoselective synthesis of arabino and ribolike. Compiles current tested and proven approaches to synthesize novel nucleoside analogues featuring contributions from leading synthetic chemists from around. What links here related changes upload file special pages permanent link page information wikidata item cite this page. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. The allcarbon stereogenic center was generated through an intramolecular 7endo attack of a silyltethered allyl moiety on a tertiary radical using photoredox catalysis. This work increases the arsenal of reactions and strategies available for the synthesis of nucleoside analogues as potential biochemical tools or new therapeutics. Efficient biocatalytic synthesis of dihalogenated purine nucleoside. Phosphonated nucleoside analogues chemical synthesis of.